Customized Services for Animal Model of Brugia malayi Infection

Customized Services for Animal Model of Brugia malayi Infection

Brugia malayi Animal Model Customization Service

Malayan filariasis is a parasitic disease caused by Brugia malayi (Malay filariasis) parasitizing the human lymphatic system, which is distributed in Asia. The clinical manifestations are recurrent lymphangitis, lymphadenitis and fever in the acute phase, and lymphedema and elephantiasis in the chronic phase, which seriously endanger the health and economic development of the population in the endemic areas. The larval stages of filarial worms are microfilariae, larvae and filarial larvae, of which microfilariae are the diagnostic stage and filarial larvae are the infective stage. It is also transmitted by mosquitoes, and microfilariae appear periodically in the peripheral blood.

Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Brugia malayi disease. This provides a good model for Brugia malayi morphology, life history and especially the molecular biology and preparation of monoclonal antibodies provided a good model.

Customization Service Options for Animal Models of Brugia malayi Infection

We can set up a Brugia malayi disease model for you in SCID mouse or long-clawed gerbil, it can be used for scientific research and drug research of Malayan filariasis. If you want to know more, you are welcome to consult us.

  • SCID mouse model of Brugia malayi

Subcutaneous inoculation of the larvae of Anopheles malayi

  • Long-clawed gerbil model of Brugia malayi
  1. Microfilariae were obtained by drawing blood from patients with Malay microfilariae (at night), or by washing microfilariae from the peritoneal cavity of gerbils infected with microfilariae.
  2. Anopheles sinensis and Aedes aegypti were infected and then reared for 7 to 9 days.
  3. The filtration method was used to collect Malay larvae during the infection period and to infect gerbils.

Service Details

Model animal selection: SCID mouse or long-clawed gerbil, Anopheles sinensis and Aedes aegypti
Other key reagents: 3.8% sodium raffinate anticoagulation.
Delivery content: experiment report and Brugia malayi disease animal model.
Test fee: please get it through online inquiry.

Service Flow

  1. Communicate your project requirements with us via online inquiry or telephone.
  2. Communicate the requirements (Number, degree of infection, etc.) of Brugia malayi disease animal model customization, sign the contract and pay the deposit.
  3. Fill out the sample order and send the samples (optional).
  4. Develop Brugia malayi disease animal model and prepare project experiment report.
  5. Delivery of report and animal model.

Our Advantages

  • We offer 2 murine species of Brugia malayi disease models, it can be used for scientific research and drug research of Brugia malayi. If you have special needs, please consult us for customization.
  • Our professional technicians have extensive experience in parasite animal model development.
  • Advanced technology platform, scientific management system, and standard R&D procedures.
  • In addition to Brugia malayi animal model customization service, we also provide Brugia malayi identification (Blood / body fluid / urine detection of microfilariae (thick blood film method, fresh blood drop method, concentration method, staining microscopy), pathology section test, immunoassay (intradermal test, indirect fluorescent antibody test (IFAT), immunoenzymatic staining test (IEST) for frozen sections of adult worms and enzyme-linked immunosorbent assay (ELISA) for soluble antigens of adult Malaysian filarial worms or microfilariae, etc.) and in vitro culture services.
  • The project cycle time is short and the price is competitive.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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