Echinococcosis granulosa is a disease caused by infection with the larvae of Echinococcus granulosus (hydatid cyst / echinococtus cyst), also known as cystic echinococcosis (CE) or unilocular echinococcosis. The fine-grained echinococcosis tapeworm is a human-animal parasite whose final hosts are canine carnivores such as dogs, jackals, and wolves. The intermediate hosts are sheep, cattle, camels and other herbivores and humans. Therefore, the disease is prevalent in livestock areas, and humans can also become its intermediate hosts by accidentally ingesting eggs and developing encrustation disease. Cysts are most common in the liver, followed by the lungs, and other organs such as the brain and bones are occasionally invaded.
The incubation period of cystic echinococcosis is long, ranging from 10 to 20 years or longer from infection to disease onset. Clinical manifestations vary depending on the site of parasitization, cyst size and the presence of complications. In the early stages of infection, there are no obvious symptoms, but in the later stages, the main symptoms include coughing, wasting, stunting, rebellious coat, and prolonged recumbency, and anaphylactic shock caused by rupture of the cyst can lead to sudden death of individual animals.
As a zoonotic parasitic disease, echinococcosis has a wide distribution, wide prevalence and high incidence, and poses a greater threat to the cattle and sheep farming industry.
Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Echinococcosis granulosus. This provides a good model for the morphology, life history and especially the molecular biology of Echinococcosis granulosus and the study of Echinococcosis granulosa.
We can establish an Echinococcosis granulosus model for you in mice, it can be used for scientific research and drug research of Echinococcosis granulosus. If you want to know more, you are welcome to consult us.
Model animals: KM mice of 6-8 weeks old and weighing about 20 g
Parasite source: eggs were collected from the gestational nodules of a domesticated sheep strain, and then the eggs were exfoliated to obtain six-hook larvae.
Replication methods: oral infection, intravenous infection, abdominal infection, and subcutaneous infection.
Model characteristics: Different sites of parasitization of encysts in mice can directly affect the growth rate and size of encysts. The infection rate of different strains of Echinococcosis granulosus. and different inoculums (e.g. eggs, protozoa, hexacercariae) varies for different modeled animals.
Application: This model can be used to understand the process and growth of eggs developing into encysts in the organism, and to understand the continuous immune response and antibody changes in the organism due to the invasion of eggs; it can also be used to observe the growth and development process of encysts, drug screening, observation of treatment effect and monitoring of various biological indicators such as immunology after the animals are infected with hexococci.
Delivery content: experiment report and Echinococcosis granulosus animal model
Test fee: please get it through online inquiry.