Customized Services for Animal Model of Capillaria hepatica Infection

Customized Services for Animal Model of Capillaria hepatica Infection

Capillaria hepatica Animal Model Customization Service

Capillaria hepatica is a human-animal parasitic nematode with a worldwide distribution that is widely found in the liver of rodents, worm-eaters, dogs, cattle, rabbits, humans and other primates. It can cause liver damage, severe liver dysfunction, liver fibrosis, and even death in the host. In humans and some animals, hepatica capillariasis is contracted by accidental ingestion of food or water contaminated with eggs of infected stages. Adult Capillaria hepatica parasites live in the liver and lay eggs in the liver parenchyma. The deposition of eggs leads to granulomatous reaction and abscess-like lesions, which are visible to the naked eye as numerous punctate pearl-like white granules on the liver surface or small gray nodules with a size of 0.1 to 0.2 cm. The abscess center consisted of adult worms, eggs and necrotic tissue, and the worms could be intact or disintegrated. The body and eggs are surrounded by eosinophil, plasma cell and macrophage infiltration. Patients may develop fever, hepatosplenomegaly, significant eosinophilia, leukocytosis, hypogammaglobulinemia and hypohemoglobinemia; severe cases may manifest as drowsiness, dehydration, or even death.

Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Capillaria hepatica. This provides a good model for the morphology, life history and especially the molecular biology of Capillaria hepatica and the study of Hepaticoliasis.

Customization Service Options for Animal Models of Capillaria hepatica Infection

We can construct a Capillaria hepatica model for you in rats, it can be used for scientific research and drug research of Hepaticoliasis. If you want to know more, you are welcome to consult us.

  • Rats model of Capillaria hepatica

Model animals: Healthy SD rats

Parasite: eggs of Capillaria hepatica

Reproduction method: transoral injection

Model characteristics: since the egg development process is not synchronized, some eggs have already developed and some have not yet developed, therefore, it is necessary to do the preliminary work of egg cultivation to establish an animal model of Capillaria hepatica infection. The degree and course of morbidity may be influenced by the amount of eggs contained via oral injection. In general, eggs or worms can be detected by autopsy at 18-28 d. After 28 d of infection, the liver of rats is enlarged, bruised and covered with yellow spots. Adult worms are only viable for 40-60 d. The dead females disintegrate and release a large number of eggs, thus causing necrosis, granulomatous inflammatory reaction and fibrosis of liver tissue.

Applications: This model can be used for understanding the life history of Capillaria hepatica, studies on the prevention and treatment of Hepaticoliasis and trials of related anti-disease drugs.

Service Details

Delivery content: experiment report and Capillaria hepatica animal model
Test fee: please get it through online inquiry.

Service Flow

  1. Communicate your requirements with us via online inquiry or telephone.
  2. Communicate the requirements (Number, degree of infection, etc.) of Capillaria hepatica animal model customization, sign the contract and pay the deposit.
  3. Fill out the sample order and send the samples (optional).
  4. Establish Capillaria hepatica animal model and prepare experiment report.
  5. Delivery of report and animal model.

Our Advantages

  • We offer rat models of Capillaria hepatica that can be used for scientific research and drug research of Hepaticoliasis. If you have special needs, please consult us for customization.
  • Our professional technicians have extensive experience in parasite animal model development.
  • Advanced technology platform, scientific management system, and standard R&D procedures.
  • In addition to Capillaria hepatica animal model customization service, we also provide Capillaria hepatica identification (Liver tissue section test, immunofluorescence test, indirect coagulation test, ELISA, etc.) and in vitro culture services.
  • The project cycle time is short and the price is competitive.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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