The life history of Leishmania spp. has a protoflagellate (promastigote) period and a flagellate-free (amastigote) period. The former is parasitic in the digestive tract of arthropods (whiteflies), while the latter is parasitic in the cells of mammals or reptiles and is transmitted through whiteflies. The common Leishmania parasites in humans are Leishmania donovani, Leishmania tropica and Leishmania braziliensis.
The non-flagellated body of Leishmania donovani is mainly parasitized in macrophages of liver, spleen, bone marrow, lymph nodes, etc. It often causes systemic symptoms, such as fever, hepatosplenomegaly, anemia, epistaxis, etc. Patients often have dark pigmentation on the skin and fever, so it is also called Kala-azar, which means black fever. It is rarely self-healing because of its strong pathogenicity, and death is often caused by co-morbidity if left untreated.
Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Leishmania donovani disease. This provides a good model for the morphology, life history and especially the molecular biology of Leishmania donovani and the study of black fever.
We can set up a Leishmania donovani disease model for you in mice, golden voles or long-clawed gerbils, it can be used for scientific research and drug research of Leishmania donovani. If you want to know more, you are welcome to consult us.
Model animal selection: mice, golden voles or long-clawed gerbils
Source of parasites: isolation and purified from the spleen of the conserved golden vole
Method: intravenous injection of Leishmania donovani at the flagellar-free stage
Delivery content: experiment report and Leishmania donovani disease animal model
Test fee: please get it through online inquiry.
The ability of different Leishmania species to infect the same model animal varies; the susceptibility of different model animals to the same Leishmania species and the response to infection also varies; individual differences in model animals affect the pathogenesis. The individual differences in the model animals affect the pathogenesis of the disease. The model animals and the Leishmania parasites can be selected according to the needs. The models replicated by this method can be used for studies of immune mechanisms and vaccines for Leishmania donovani.