Hymenolepis diminuta, also known as the long cestode, is a human-animal parasite. It is mainly parasitic in rodents, but occasionally also in dogs, monkeys and humans. Its intermediate hosts are mainly beetles, fleas, cockroaches and more than 20 other arthropods, while rat fleas and flour beetles are the main natural intermediate hosts. Final hosts such as rats and humans are infected by ingesting intermediate hosts with cysticercus larvae. Most infected individuals have no obvious clinical symptoms or only mild neurological and gastrointestinal symptoms such as headache, insomnia, teeth grinding, nausea, abdominal distension and abdominal pain. Severely infected individuals may develop vertigo, anemia, mental dementia or cachexia. Its gravid or eggs are excreted with the feces of the final host, swallowed by the intermediate host and then hatch in its digestive tract as hexacercariae, which then pass through the intestinal wall into the blood.
Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Hymenolepis diminuta. This provides a good model for the morphology, life history and especially the molecular biology of Hymenolepis diminuta.
We can establish an Hymenolepis diminuta model for you in rats, it can be used for scientific research and drug research of Hymenolepis diminuta. If you want to know more, you are welcome to consult us.
Model animals: rat (and Tribolium castaneum)
Source of parasite: eggs from fresh feces of positive Hymenolepis diminuta rats.
Reproduction method: the eggs of Hymenolepis diminuta were artificially fed/infected with newly reproduced Tribolium castaneum; after 14 d Tribolium castaneum was dissected and live cysticercoid were collected and placed in saline. They were then injected into the stomach of healthy rats.
Model characteristics: on the 18th day after infection, rats can be positive for fecal examination of eggs or gravid proglottids.
Application: the animal model replicated by this method can be used to study the interaction between Hymenolepis diminuta and humans, the diagnosis of Hymenolepis diminuta infection and its prevention and treatment.
Delivery content: experiment report and Hymenolepis diminuta animal model
Test fee: please get it through online inquiry.