Encephalitozoon cuniculi is a specialized intracellular parasite found mainly in the cells of the brain, kidney, ascites macrophages, liver, spleen and other tissues and organs of rabbits, mice, rats, pigs, dogs, sheep and monkeys. Encephalitozoonosis is a chronic, cryptogenic protozoan disease caused by Encephalitozoon cuniculi. The worm mainly attacks brain tissue and kidneys, and the lesions are characterised by granulomatous encephalitis and granulomatous nephritis. The lesions are characterised by granulomatous encephalitis and granulomatous nephritis. The worms accumulate in mounds in the centre of the necrosis and the necrotic area is surrounded by an infiltration of lymphocytes, plasma cells, microglia and epithelial cells; sometimes there is an infiltration of macrophages and a vascular sheath formed by aggregations of lymphocytes and plasma cells around the vessels. Symptoms of encephalitis and nephritis are sometimes seen.
Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services forEncephalitozoon cuniculi. This provides a good model for the morphology, life history and especially the molecular biology of Encephalitozoon cuniculi.
We can establish an Encephalitozoon cuniculi model for you in rabbits, puppies, guinea pigs, it can be used for scientific research and drug research of Encephalitozoonosis. If you want to know more, you are welcome to consult us.
Model animals: rabbit, puppies, guinea pig and others.
Source of parasite: purified and collected Encephalitozoon cuniculi from the faeces of affected rabbits.
Reproduction method: oral, gavage or intranasal inoculation.
Model characteristics: the main organs of the infected animals have a large infiltration of inflammatory cells, and the cortical region of the kidney has a large number of granulomas centred on the worm and surrounded by lymphocytes, plasma cells and macrophages. Granulomatous lesions surrounded by lymphocytes, plasma cells, microglia and epithelial cells were seen in the brain parenchyma. The epithelium of the biliary tract is necrotic and detached.
Application: A powerful tool for the study of the pathogenesis and its specific control of Encephalitozoonosis.
Delivery content: experiment report and Encephalitozoon cuniculi animal model
Test fee: please get it through online inquiry.